Holidaymakers travelling with British Airways are facing delays and problems checking in online, with the airline saying system failures are to blame.
Customers at UK airports have taken to social media to complain about long queues, flight delays and the app crashing.
At Heathrow, 81 flights have been cancelled while BA have cancelled 10 Gatwick flights.
BA said it is reverting to manual systems for check-in at airports.
More than 200 flights have been delayed across the UK, with the airline advising customers to allow extra time at airports.
“Please check ba.com and manage my booking for the latest flight information and allow extra time at the airport.”
It said the issue was not a global outage, but a problem with two separate systems – one which deals with online check in, the other that deals with flight departures.
The problems are affecting flights across its network but not at every airport, it added.
On Twitter, one holidaymaker at Gatwick Airport said he was stuck on the ground because the “pilot can’t get data”.
Another disgruntled customer at Manchester Airport said he was meant to be on the BA1385 flight, but was told at the gate that there was a “worldwide British Airways system outage”.
British Airways said it is working as quickly as possible to resolve the systems issue which “has resulted in some short-haul cancellations and delays from London airports.”
It said: “We are offering customers booked on short-haul services departing from Heathrow, Gatwick and London City today, the opportunity to rebook to another day.”
Speaking to BBC News, Kieran Healey-Ryder, from Glasgow, said he chose to disembark his 0700 BST flight from Glasgow to London following a two-hour delay.
“We boarded at about 06.30am and pretty quickly they said there had been an IT outage across their network and they were unable to depart,” he said.
Passengers, including holidaymakers and people travelling to a whisky event in London, were told the outage was affecting “BA planes specifically”.
Some began to disembark after about half an hour, Mr Healey-Ryder said.
He added: “Unfortunately it doesn’t look like we’ll be making it down to London today.”
Holidaymakers and rush-hour commuters have also faced delays and cancellations due to three fires which broke out next to railway tracks near Victoria Station.
Southern said the fires had been put out and lines reopened but residual delays are expected to last until about 14:30 BST.